The Industrial Age of Biocatalytic Transamination
نویسندگان
چکیده
منابع مشابه
The Industrial Age of Biocatalytic Transamination
During the last decade the use of ω-transaminases has been identified as a very powerful method for the preparation of optically pure amines from the corresponding ketones. Their immense potential for the preparation of chiral amines, together with their ease of use in combination with existing biocatalytic methods, have made these biocatalysts a competitor to any chemical methodology for (asym...
متن کاملAmination of ω-Functionalized Aliphatic Primary Alcohols by a Biocatalytic Oxidation–Transamination Cascade
Amination of non-activated aliphatic fatty alcohols to the corresponding primary amines was achieved through a five-enzyme cascade reaction by coupling a long-chain alcohol oxidase from Aspergillus fumigatus (LCAO_Af) with a ω-transaminase from Chromobacterium violaceum (ω-TA_Cv). The alcohol was oxidized at the expense of molecular oxygen to yield the corresponding aldehyde, which was subseque...
متن کاملThe stereochemistry of enzymatic transamination.
An approach to the determination of the complete stereochemistry of enzymatic transamination is described. Stereospecificity in the enzymatic labilization of one of the 4-methylene protons of pyridoxamine has been demonstrated in the transamination of pyridoxamine catalyzed by apoglutamate-oxaloacetate transaminase. Both enantiomers of the 4-(CHD-NH2) pyridoxamine have been prepared. These comp...
متن کاملSpectrophotometric Measurement of Transamination
In a previous publication (1) from this laboratory, it was demonstrated that the transamination of amino acids to a-ketoglutaric acid is a reaction of wide scope. Although the data reported in the earlier paper permitted the computation of Q transaminase values, these values were of limited quantitative significance since no attempt was made to study the kinetics of these reaction systems, the ...
متن کاملLearning And Education After the Industrial Age
Introduction and Summary Each historical era creates a system of education that addresses its needs. In the 19th century, the educational revolution was driven by a radical shift from family-centric production to manufacturing and industrial organization, and the associated rapid urbanization and social mobility in industrializing countries. In this process, the home, the workplace, community l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2015
ISSN: 1434-193X
DOI: 10.1002/ejoc.201500852